Affordable Access

The importance of liposomes as models and tools in the understanding of photosensitization mechanisms

Authors
Publication Date
Keywords
  • Liposomes
  • Photosensitization
  • Photodynamic Therapy
  • Physical
  • Chemical
  • Mathematical & Earth Sciences :: Physics [G04]
  • Physique
  • Chimie
  • Mathématiques & Sciences De La Terre :: Physique [G04]
Disciplines
  • Chemistry
  • Medicine

Abstract

The various applications of liposomes in understanding photosensitization are described in this paper, with particular emphasis on the various kinds of information that these models allow to obtain in phototherapy. Liposomes are simple vesicles in which an aqueous phase is enclosed by a phospholipidic membrane. They are suitable models mimicking specific situations occurring <br />m vivo and they allow study of the influence of physieochemieal, photobioiogieal and biochemical factors on the uptake of photosensitizers by tissues, their mechanisms of action and the subsequent photoinduced tumor necrosis. Moreover, solubilization of the sensitizer into the bilayer seems to improve its tumoral selectivity and its photodynamic efficiency.

There are no comments yet on this publication. Be the first to share your thoughts.