“The world hath noted, and your name is great…” [Act II. Scene III. Othello, the Moor of Venice, by William Shakespeare]. The Name Game was a popular rock and roll song performed by the singer, Shirley Ellis, in 1965. Most people who were adolescents at that time will undoubtedly be able to recall the music and possibly some of the lyrics (“Shirley, Shirley bo Birley Bonana fanna fo Firley, Fee fy mo Mirley, Shirley!…”). In a variation of the name game strategy, this article proposes to use words that are composed of the letters of the English alphabet, such as surnames and given names, as a source of ideas for the design of novel, bioactive peptides. An example that uses the name of the current United States Secretary of State, Colin Powell, is provided to illustrate the hypothesis presented.