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Role of Ca2+channels in short-term synaptic plasticity

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
17
Issue
3
Identifiers
DOI: 10.1016/j.conb.2007.04.005
Disciplines
  • Computer Science

Abstract

Repetitive nerve activity induces various forms of short-term synaptic plasticity that have important computational roles in neuronal networks. Several forms of short-term plasticity are caused largely by changes in transmitter release, but the mechanisms that underlie these changes in the release process have been difficult to address. Recent studies of a giant synapse — the calyx of Held — have shed new light on this issue. Recordings of Ca 2+ currents or Ca 2+ concentrations at nerve terminals reveal that regulation of presynaptic Ca 2+ channels has a significant role in three important forms of short-term plasticity: short-term depression, facilitation and post-tetanic potentiation.

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