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Peroxisome proliferator-activated receptors are expressed in mouse bone marrow-derived mast cells

Authors
Journal
FEBS Letters
0014-5793
Publisher
Wiley Blackwell (John Wiley & Sons)
Publication Date
Volume
467
Identifiers
DOI: 10.1016/s0014-5793(00)01169-8
Keywords
  • Peroxyzome Proliferator-Activated Receptor
  • Mast Cell
  • Cytokine

Abstract

Abstract We examined the expression of peroxisome proliferator-activated receptors (PPARs) and the role of PPARs in cytokine production in mouse bone marrow-derived mast cells (mBMMCs). mBMMCs expressed PPARβ strongly and γ slightly, but not α. Activation of mBMMCs with antigen or calcium ionophore resulted in the increased expression of PPARγ mRNA specifically. 15-Deoxy-Δ 12,14-prostaglandin J 2 (15d-PGJ 2) and troglitazone, all PPARγ ligands, attenuated the antigen-induced cytokine production by mBMMCs. Carbaprostacyclin, a PPARβ ligand, also inhibited cytokine production, whereas PPARα ligands did not. These results suggest that PPARβ and γ might be included in the negative regulation of mast cell activation.

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