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Protective immunity against avian influenza induced by a fowlpox virus recombinant

Authors
Journal
Vaccine
0264-410X
Publisher
Elsevier
Publication Date
Volume
6
Issue
6
Identifiers
DOI: 10.1016/0264-410x(88)90101-6
Keywords
  • Avian Influenza
  • Fowlpox Virus
  • Recombinant Dna

Abstract

Abstract Fowlpox virus, the prototypic virus of the genus Avipoxvirus has a natural host range limited to avian species. As such, fowlpox virus provides a suitable candidate for the development of a species-specific recombinant viral vector. This paper reports the development of a fowlpox virus recombinant expressing the haemagglutinin molecule from a highly virulent avian influenza virus. On immunization of chickens and turkeys with the recombinant, protection is afforded against a lethal challenge with either the homologous or a heterologous influenza virus strain.

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