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The inner gel component of Aloe vera suppresses bacterial-induced pro-inflammatory cytokines from human immune cells

Authors
Journal
Methods
1046-2023
Publisher
Elsevier
Publication Date
Volume
42
Issue
4
Identifiers
DOI: 10.1016/j.ymeth.2007.03.005
Keywords
  • Aloe Vera
  • Anti-Inflammatory
  • Inflammation
  • Pro-Inflammatory Cytokines
Disciplines
  • Design

Abstract

Abstract The present study was carried out to examine the anti-inflammatory activity of the inner leaf gel component of Aloe barbadensis Miller. A simple in vitro assay was designed to determine the effect of the inner gel on bacterial-induced pro-inflammatory cytokine production, namely TNF-α and IL-1β, from peripheral blood leukocytes stimulated with Shigella flexneri or LPS. This report describes the suppression of both cytokines with a freeze-dried inner gel powder and a commercial health drink from the same source. Comparison was made with a human monocytic cell-line (THP-1 cells) and a similar trend in responses was demonstrated.

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