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Enhancement of enzymatic production of cyclodextrins by adding polyethylene glycol or polypropylene glycol

Authors
Journal
Journal of Fermentation and Bioengineering
0922-338X
Publisher
Elsevier
Publication Date
Volume
73
Issue
3
Identifiers
DOI: 10.1016/0922-338x(92)90170-y
Disciplines
  • Biology

Abstract

Abstract Enzymatic production of cyclodextrins (CDs) from soluble starch was studied using either Bacillus macerans or Bacillus ohbensis cyclomaltodextrin glucanotransferase (CGTase). The production yield of CDs was found to be increased up to 1.5–2 times by the addition of low molecular weight polyethylene glycol (PEG 400) or polypropylene glycol (PPG 425) to the reaction medium. Such results were interpreted as being due to a conformational change of the substrate as well as reduction of hydrolytic activity of the enzyme in the presence of these additives.

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