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Influence of penicillinase production by strains ofBacteroides melaninogenicusandBacteroides oralison penicillin therapy of an experimental mixed anaerobic infection in mice

Authors
Journal
Archives of Oral Biology
0003-9969
Publisher
Elsevier
Publication Date
Volume
21
Issue
6
Identifiers
DOI: 10.1016/s0003-9969(76)80007-6
Disciplines
  • Medicine

Abstract

Summary A mixed infection in mice involving a penicillin-susceptible pathogen, Fusobacterium necorphorum and strains of either Bacteroides melaninogenicus or Bacteroides aralis was resistant to penicillin therapy when penicillin-resistant Bacteroides strains were used but not when penicillin-susceptible strains were used. The ability of penicillin-resistant strains of Bact. melaninogenicus and Bact. oralis to protect F. necrophorum from penicillin in vivo appeared to be due to β-lactamase production by these strains. In vitro β-lactamase activity could be demonstrated in Bacteroides strains which protected F. necropharum in vivo, but not in strains which failed to give protection.

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