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Effects induced by the electrical stimulation of the nucleus raphe dorsalis upon hypothalamic release of 5-hydroxyindole compounds and sleep parameters in the rat

Authors
Journal
Brain Research
0006-8993
Publisher
Elsevier
Publication Date
Volume
565
Issue
1
Identifiers
DOI: 10.1016/0006-8993(91)91735-j
Keywords
  • Sleep
  • Sleep Rebound
  • Electrical Stimulation
  • Serotonin
  • 5-Hydroxyindoleacetic Acid
  • P-Chlorophenylalanine
  • Voltammetry
  • Nucleus Raphe Dorsalis
  • Hypothalamus

Abstract

Abstract Electrical stimulation (30 min, pulse 0.5 ms, 150 μA, 20 Hz) of the antero-dorsal part of the nucleus raphe dorsalis (n.RD) induces in the basal hypothalamus (n. arcuate and surrounding areas) a large axonal release of 5-hydroxyindole compounds (5-OH Les; about +300%) measured by means of voltammetric technique. During such a release, evidence for a direct detection of serotonin (5-HT) is reported. The above stimulation induces also marked aversive behaviors together with prolonged polygraphic arousal. Three hours later, a significant paradoxical sleep (PS) rebound occurs. Both the 5-OH Les release and the PS rebound observed after n.RD stimulation are suppressed by a p-chlorophenylalanine (PCPA) pretreatment of the animals. The 5-HT-hypogenic factor dependence of the PS rebound observed after n.RD stimulation is discussed.

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