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Rare-earth-incorporated polymeric vector for enhanced gene delivery

Authors
Journal
Biomaterials
0142-9612
Publisher
Elsevier
Volume
35
Issue
1
Identifiers
DOI: 10.1016/j.biomaterials.2013.09.069
Keywords
  • Pei-Cyd
  • Neodymium
  • Energetic Ions
  • Plasma Treatment
  • Cellular Pathways

Abstract

Abstract Cationic polymer PEI-CyD is doped with Nd by plasma technology to produce the gene vector: [email protected] Luciferase expression and EGFP transfection experiments performed in vitro reveal that [email protected] has significantly higher transfection efficiency than lipofectamine 2000 and PEI-CyD and the mechanism is studied and proposed. The rare-earth element, Nd, stimulates the energy metabolism of cells, enhances cell uptake of complexes/pDNA, and regulates the cellular pathways. These special features suggest a new strategy involving metal-incorporated non-viral gene vectors.

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