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Effect of prostaglandin D2and I2on the airways of rhesus monkeys

Authors
Journal
Journal of Allergy and Clinical Immunology
0091-6749
Publisher
Elsevier
Publication Date
Volume
65
Issue
4
Identifiers
DOI: 10.1016/0091-6749(80)90154-2
Disciplines
  • Medicine

Abstract

Abstract Prostaglandin (PG) D 2 and PGI 2 were evaluated to determine their effect on pulmonary function parameters when aerosolized in anesthetized rhesus monkeys. PGD 2 resulted in an increase in frequency (f) and pulmonary resistance (R L) and a decrease in peak expiratory flow rate (PEFR), tidal volume (V T), and dynamic compliance (Cdyn), with the major effect on R L. PGI 2 primarily effected an increase in f and a decrease in PEFR and V T. PGI 2 had a variable effect, generally a decrease, on R L. The metabolite of PGI 2 , 6-keto-PGF 1α , had no effect on the rhesus airway. PGF 2α responses were similar to PGD 2 except that the PGF 2α produced a less strikingly consistent increase in R L. When PGI 2 and PGD 2 were aerosolized simultaneously, they simulated previously described antigen responses. Further, PGI 2 plus PGD 2 produced an airway response at 1 10 the concentration of either agent alone.

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