Affordable Access

Publisher Website

Synthesis of the enantiomers of felodipine and determination of their absolute configuration

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
30
Issue
46
Identifiers
DOI: 10.1016/s0040-4039(01)93912-7

Abstract

Abstract The pure enantiomers of felodipine, 1, have been synthesized by chromatographic separation of diastereomeric esters with (R)-1-(p-toluenesulfonyl)-3-trityloxypropan-2-ol, 3, as an easily removable chiral auxiliary. Absolute configurations have been deduced via X-ray crystallography on a (R)-mandelic acid ester, 9B.

There are no comments yet on this publication. Be the first to share your thoughts.