Abstract Our present study belongs to a broader research project, targeting the training optimization in performance volleyball through stress control, based upon Women's A1 Division Penicilina Iasi volleyball team, during the 2011-2012 season. With the present proposal, we aim at discussing the levels of competitive stress, as revealed by neurotransmitters within cells and their possible interpretations. The participants our research, namely ten athletes playing for Penicilina Iasi volleyball team, were the subject of DDFAO lab tests. The probes were taken during three key-moments of the competitive season: after the holydays, after returning from the mountain training camp, and right before the most important game in the championship (the last chance to avoid relegation). Our research was based on two initial assumptions: 1. During different stages of the competitive season, players’ stress levels vary; 2. stress levels can improve through specific mental and physical training methods. The final results confirmed our hypothesis.