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Evaluation of B-type Natriuretic Peptide for validation of a heart failure register in primary care

Authors
Journal
BMC Cardiovascular Disorders
1471-2261
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
7
Issue
1
Identifiers
DOI: 10.1186/1471-2261-7-23
Keywords
  • Research Article

Abstract

1471-2261-7-23.fm ral ss BioMed CentBMC Cardiovascular Disorders Open AcceResearch article Evaluation of B-type Natriuretic Peptide for validation of a heart failure register in primary care Gurbir S Bhatia1, Michael D Sosin1, Jane Stubley1, Jeetesh V Patel2, Elizabeth A Hughes2, Rebecca Gibbs3 and Russell C Davis*1 Address: 1Department of Cardiology, Sandwell & West Birmingham Hospitals NHS Trust, Lyndon, West Bromwich, B71 4HJ, UK, 2Department of Pathology, Sandwell & West Birmingham Hospitals NHS Trust, Lyndon, West Bromwich, B71 4HJ, UK and 3Regis Medical Centre, Darby Street, Rowley Regis, West Midlands, B65 0BA, UK Email: Gurbir S Bhatia - [email protected]; Michael D Sosin - [email protected]; Jane Stubley - [email protected]; Jeetesh V Patel - [email protected]; Elizabeth A Hughes - [email protected]; Rebecca Gibbs - [email protected]; Russell C Davis* - [email protected] * Corresponding author Abstract Background: Diagnosing heart failure and left ventricular systolic dysfunction is difficult on clinical grounds alone. We sought to determine the accuracy of a heart failure register in a single primary care practice, and to examine the usefulness of b-type (or brain) natriuretic peptide (BNP) assay for this purpose. Methods: A register validation audit in a single general practice in the UK was carried out. Of 217 patients on the heart failure register, 56 of 61 patients who had not been previously investigated underwent 12-lead electrocardiography and echocardiography within the practice site. Plasma was obtained for BNP assay from 45 subjects, and its performance in identifying echocardiographic abnormalities consistent with heart failure was assessed by analysing area under receiver operator characteristic (ROC) curves. Results: 30/217 were found to have no evidence to suggest heart failure on notes review and were probably incorrectly coded. 70/112 who were previously investigated were confirmed to have heart

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