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Synergistic interactions of proinflammatory cytokines with oncostatin M: production of active collagenases and implications for joint destruction

Arthritis Research & Therapy
Springer (Biomed Central Ltd.)
Publication Date
DOI: 10.1186/ar1383
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S1 Available online Message from World Health Organization Health needs assessment of musculoskeletal conditions: an international bone and joint burden of disease study N Khaltaev1, B Pfleger1, AD Woolf2, K Åkesson3, JM Hazes4, D Symmons5, and the Bone and Joint Monitor Group 1Management of Noncommunicable Diseases, World Health Organization, Geneva, Switzerland; 2Duke of Cornwall Rheumatology Department, Royal Cornwall Hospital, Truro, UK; 3Department of Orthopaedic Surgery, Malmö University Hospital, Malmö, Sweden; 4Department of Rheumatology, University Hospital of Rotterdam, The Netherlands; 5Epidemiology Research Unit, University of Manchester, UK Arthritis Res Ther 2004, 6(Suppl 3):103 (DOI 10.1186/ar1334) Introduction The Bone and Joint Monitor Project was developed to quantify the global burden of musculoskeletal conditions and develop strategies for their prevention. Experts within the Monitor Project have worked previously with officers at the World Health Organization (WHO) to estimate morbidity and mortality associated with rheumatic conditions. The present collaboration seeks means of providing addi- tional and more current burden data. Objective To develop recommendations for performing epidemiologi- cal studies in sample populations with musculoskeletal conditions and problems, accounting for determinants and consequences to the indi- vidual and society. Methods Recommendations have been developed identifying the most relevant domains for measuring and monitoring the various muscu- loskeletal conditions by review of epidemiological data on occurrence, determinants and outcomes, and by expert opinion. Instruments that measure these domains were reviewed. Results The domains recommended follow the principles of the WHO International Classification of Functioning, Disability and Health [1,2], and consider: health condition; body function and structure; activity lim- itation; participation restriction; personal and environmental

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