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Effects of in vivo exposure to antineoplastic drugs on DNA repair and replication in human lymphocytes

Authors
Journal
Mutation Research Letters
0165-7992
Publisher
Elsevier
Publication Date
Volume
245
Issue
3
Identifiers
DOI: 10.1016/0165-7992(90)90053-m
Keywords
  • Unscheduled Dna Synthesis
  • Uv-Induced
  • Lymphocyte Stimulation By Phytohaemagglutinin
  • Inhibition Of Dna Synthesis
Disciplines
  • Medicine

Abstract

Abstract In peripheral blood lymphocytes of 12 nurses and 3 patients exposed to antineoplastic drugs we determined the ability to repair DNA after UV irradiation and DNA replicative synthesis after stimulation by PHA. In nurses the levels of unscheduled DNA synthesis and DNA replication were not different than in a control group, whereas in patients significant changes were observed during and after chemotherapy in the level of both types of DNA synthesis.

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