Affordable Access

Publisher Website

MIF: metastasis/MDSC-inducing factor?

Authors
Journal
OncoImmunology
2162-4011
Publisher
Landes Bioscience
Publication Date
Volume
2
Issue
3
Identifiers
DOI: 10.4161/onci.23337
Keywords
  • Author'S View
Disciplines
  • Medicine

Abstract

Myeloid-derived suppressor cells (MDSCs) promote tumor growth and metastasis. We have recently demonstrated that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) enhances the immunosuppressive microenvironment by increasing the abundance of monocytic MDSCs within the tumor. Our results suggest that MIF is a potential therapeutic target for the prevention of metastasis as it regulates the tumor microenvironment.

There are no comments yet on this publication. Be the first to share your thoughts.