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MIF: metastasis/MDSC-inducing factor?

Authors
Journal
OncoImmunology
2162-4011
Publisher
Landes Bioscience
Publication Date
Volume
2
Issue
3
Identifiers
DOI: 10.4161/onci.23337
Source
Legacy
Keywords
  • Author'S View
Disciplines
  • Medicine

Abstract

Myeloid-derived suppressor cells (MDSCs) promote tumor growth and metastasis. We have recently demonstrated that the pro-inflammatory cytokine macrophage migration inhibitory factor (MIF) enhances the immunosuppressive microenvironment by increasing the abundance of monocytic MDSCs within the tumor. Our results suggest that MIF is a potential therapeutic target for the prevention of metastasis as it regulates the tumor microenvironment.

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