Affordable Access

BI-BII transitions in B-DNA.

Authors
Publication Date
Source
PMC
Disciplines
  • Mathematics

Abstract

Molecular modelling is used to study the conformational and energetic aspects of BI-BII transitions within the backbone of a B-DNA dodecamer d(CATGACGTCATG) whose fine structure has previously been determined by molecular modelling combined with NMR spectroscopy. It is shown that while the dodecamer under investigation does not contain any BII junctions, the central CpG step can most easily undergo the transition. More generally, it is also found that the base sequence and hence the backbone geometry of a DNA segment, strongly influences both the conformational impact of the transition, the associated energy barrier and the stability of the resulting BII state.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

BI-BII transitions in B-DNA.

on Nucleic Acids Research Feb 11, 1993

Synthesis, structures, and phase transitions of ba...

on Journal of Solid State Chemist... Jan 01, 2010
More articles like this..