Affordable Access

Publisher Website

Effects of crude herbal ingredients on intrauterine infection in a rat model

Authors
Journal
Current Therapeutic Research
0011-393X
Publisher
Elsevier
Publication Date
Volume
59
Issue
2
Identifiers
DOI: 10.1016/s0011-393x(98)85007-8
Keywords
  • Juzen-Taiho-To (Shi-Quan-Da-Bu-Tang)
  • Ryutan-Shakan-To (Long-Dan-Xie-Gan-Tang)
  • Crude Herbal Ingredient
  • Uterine Endometritis
Disciplines
  • Biology

Abstract

Abstract We investigated the effects of crude ingredients that compose Juzen-taiho-to (Shi-quan-da-bu-tang) and Ryutan-shakan-to (Long-dan-xie-gan-tang) using in vitro and in vivo experimental models. Juzen-taiho-to consists of 10 crude ingredients extracted from herbs: Astragali Radix, Glycyrrhizae Radix, Cinnamomi Cortex, Rehmanniae Radix, Paeoniae Radix, Cnidii Rhizoma, Atractylodis Lanceae Rhizoma, Angelicae Radix, Ginseng Radix, and Hoelen. Ryutan-shakan-to consists of 9 crude ingredients extracted from herbs: Scutellariae Radix, Glycyrrhizae Radix, Gardeniae Fructus, Rehmanniae Radix, Plantaginis Semen, Alismatis Rhizoma, Angelicae Radix, Akebiae Caulis, and Gentianae Scabrae Radix. For the in vitro experiment, the minimum inhibitory concentration of each extract of crude ingredient against Escherichia coli (GOG 0020) was > 100 μg/mL. For the in vivo experiment, 16 hours after inoculating rats with 8.1 × 10 6 colony-forming units of E coli, each extract of crude ingredient (125 mg/kg in 1 mL physiologic saline) orally three times a day or 1 mL physiologic saline alone (control) was administered to rats by gavage orally three times a day for 7 days. The extracts showed no in vitro antimicrobial activity, but extracts of Hoelen, Rehmanniae Radix, Glycyrrhizae Radix, Cinnamomi Cortex, Cnidii Rhizoma, Angelicae Radix, and Alismatis Rhizoma in both regimens significantly decreased the viable E coli counts in rat uterine infections.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Effects of crude herbal ingredients on serum level...

on Current Therapeutic Research Jan 01, 2000

Therapeutic effects of herbal medicines (Juzen-tai...

on Current Therapeutic Research Jan 01, 1997

[Effects of active ingredients in three kidney-ton...

on Zhong xi yi jie he xue bao = J... February 2011

Genital mycoplasmosis in rats: a model for intraut...

on American journal of reproducti... September 2001
More articles like this..