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If there is LV myocardial fibrosis should we expect to find RV myocardial fibrosis? A cardiovascular MRI study

Authors
Journal
Journal of Cardiovascular Magnetic Resonance
1097-6647
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
14
Identifiers
DOI: 10.1186/1532-429x-14-s1-p151
Keywords
  • Poster Presentation
Disciplines
  • Biology
  • Design
  • Medicine

Abstract

If there is LV myocardial fibrosis should we expect to find RV myocardial fibrosis? A cardiovascular MRI study POSTER PRESENTATION Open Access If there is LV myocardial fibrosis should we expect to find RV myocardial fibrosis? A cardiovascular MRI study Robert W Biederman*, Saundra Grant, Ronald B Williams, Vikas K Rathi, Mark Doyle, June Yamrozik From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Summary In HCM, LGE defined LV fibrosis is commonplace and generally not considered in the RV. However, by CMR- LGE it may be more commonplace than expected. Background CMR has become the leading technique to detect hyper- trophic cardiomyopathy (HCM) providing complete cov- erage of both ventricles with high spatial resolution. Late gadolinium enhancement (LGE) accurately identi- fies regions of myocardial fibrosis. Via CMR, innumer- able studies have established LVH as the predominant phenotypic expression. It is well known that myocardial fibrosis can occur in patients with HCM and is indepen- dently linked to worse prognosis than those without fibrosis by CMR. The genotypic expressions would appear to affect the entire heart yet, conventionally; descriptions have been limited to the LV, likely due to the inability to image the smaller, thinner RV. Thus, lit- tle information is available about the RV in HCM. We hypothesize there may be RV involvement in HCM when incorporating CMR analysis for RV hypertrophy and fibrosis. Methods Review of all patients referred for HCM was performed. SSFP/LGE was used to diagnose patients with HCM, using gadolinium administration (MultiHance, 0.15mmol/kg, Bracco Diagnostics, Princeton, NJ). Post- injection LGE images were obtained via T1-weighted, IR preps. Regions of myocardium with abnormally high sig- nals (>2SD) were designated as fibrotic. LV/RVMass Index was calculated. Results Via 99 patients referred for HCM from 2006-2011, 28 (28%) were confirmed to be HCM via CMR. Image quality was judged excellent in 27/28 (

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