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An integrated approach for the mechanisms responsible for atherosclerotic plaque regression

Authors
Publisher
Pulsus Group Inc
Publication Date
Keywords
  • Review
Disciplines
  • Biology
  • Medicine
  • Pharmacology

Abstract

Atherosclerosis is the leading cause of death worldwide. Plaque regression – the return of the arterial wall to its initial state – is a complex process involving specific cellular and molecular pathways that are able to mobilize all pathological components of the plaque. High-density lipoproteins, endothelial cells and vascular smooth muscle cells play important roles in the progression and regression of atherosclerosis. This article describes many aspects of the atherosclerotic process and integrates the information to provide a comprehensive review of plaque regression – an understanding of which is essential to developing targeted pharmaceutical treatment strategies.

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