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A Genetically Retargeted Adenoviral Vector Enhances Viral Transduction in Esophageal Carcinoma Cell Lines and Primary Cultured Esophageal Resection Specimens

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PMC
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  • Original Articles

Abstract

The transduction efficiency of an integrin-retargeted adenoviral vector was analyzed in established cell lines, primary cultured human esophageal carcinoma cells, and normal squamous epithelial cells. It was demonstrated that this retargeted virus infects esophageal carcinoma cells more efficiently and more specifically when compared to the parental virus.

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