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Genetic polymorphism of rabbit immunoglobulins: Description ofb98, a ninth allele at the κb-locus

Authors
Journal
Molecular Immunology
0161-5890
Publisher
Elsevier
Publication Date
Volume
19
Issue
4
Identifiers
DOI: 10.1016/0161-5890(82)90225-5
Disciplines
  • Design

Abstract

Abstract A previously undetected allotypic specificity, A98, was found in a wild rabbit ( Oryctolagus cuniculus) population of Portugal. Although cross-reacting with anti-b4 and anti-b95 sera, the A98 allotype carries its own antigenic determinants and is therefore distinct from the known allotypes of the b-series. Inherited as an allotypic specificity of the b-series, A98 is located on the κ light chains of immunoglobulins but its expression requires association between light and heavy chains. Taken together these data confirm that A98 is encoded by an allele at the b-locus, tentatively designated b98.

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