Publisher Summary The chapter discusses decontamination activities. The chapter describes decontamination as the process of removing or neutralizing a chemical, radiological, biological, or mixed waste that collects on workers, personnel, or equipment while work is performed. Contamination control is a critical element to consider when trying protecting the workers, the public, and the environment when working with hazardous materials. Worker and equipment decontamination is a major concern when dealing with hazardous materials. It is important that PMs understand the importance of decontamination and contamination control when planning these activities. Anything that enters an exclusion zone should be evaluated as potential contamination. Decontamination protocols should be designed to remove hazardous substances from workers, personal protective equipment (PPE), and other equipment exiting in contaminated areas. A protocol could be as simple as doffing PPE and placing it into appropriate containers for disposal or decontamination. Appropriate procedures should be developed and implemented to help minimize contamination, prevent the spread, and decontaminate workers and equipment when they exit any contaminated area. Contamination control processes specified in the safety plan must be periodically evaluated for effectiveness and modified to correct any deficiencies noted.