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Tespa1 is a novel inositol 1,4,5-trisphosphate receptor binding protein in T and B lymphocytes

Authors
Journal
FEBS Open Bio
2211-5463
Publisher
Wiley Blackwell (John Wiley & Sons)
Volume
2
Identifiers
DOI: 10.1016/j.fob.2012.08.005
Keywords
  • Tespa1
  • Ip3R
  • Protein–Protein Interaction
  • Thymus
  • Spleen
  • Lymphocyte
Disciplines
  • Biology

Abstract

Abstract Tespa1 has been recently reported to be a critical molecule in T-cell development, however, the precise molecular mechanisms of Tespa1 remain elusive. Here, we demonstrate that Tespa1 shows amino-acid sequence homology to KRAS-induced actin-interacting protein (KRAP), an inositol 1,4,5-trisphosphate receptor (IP3R) binding protein, and that Tespa1 physically associates with IP3R in T and B lymphocytes. Two-consecutive phenylalanine residues (Phe185/Phe186) in Tespa1, which are conserved between Tespa1 and KRAP, are indispensable for the association between Tespa1 and IP3R. These findings suggest that Tespa1 plays critical roles in the immune system through the regulation of the IP3R.

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