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Benzimidazole as deazapurine analogue for microbial transglycosylation

Authors
Journal
Journal of Molecular Catalysis B Enzymatic
1381-1177
Publisher
Elsevier
Publication Date
Volume
29
Identifiers
DOI: 10.1016/j.molcatb.2003.10.007
Keywords
  • Benzimidazole
  • Whole Cells
  • Microbial Transglycosylation
  • Nucleoside Analogues
Disciplines
  • Biology
  • Chemistry
  • Pharmacology

Abstract

Abstract Benzimidazole nucleosides are compounds with interesting pharmacological properties. Although chemical synthesis of these analogues has been carried out, only few derivatives have been obtained so far using biotransformations. We report herein the biocatalysed preparation of benzimidazole ribo- and 2′-deoxyribonucleosides by different microbial whole cells that afforded yields between 75 and 85%.

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