Affordable Access

Publisher Website

Histological subtype is the most important determinant of survival in metastatic papillary thyroid cancer

Authors
Journal
Thyroid Research
1756-6614
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
4
Issue
1
Identifiers
DOI: 10.1186/1756-6614-4-12
Keywords
  • Research
Disciplines
  • Biology
  • Medicine

Abstract

Background Papillary thyroid cancer (PTC) comprises the commonest type of thyroid cancer and carries the highest rate of survival. However, when metastatic disease occurs, survival is significantly affected. Methods We aimed to identify prognostic histopathological and clinical factors that modify survival in metastatic PTC. All cases of metastatic PTC treated at our department in the last 20 years were reviewed and analyzed. Results Histological subtype was the most important determinant of survival, as classic PTC demonstrated clearly improved survival compared to follicular subtype of PTC and other less frequently seen histological subtypes. The instant risk of death for the other histological subtypes was 4.56 times higher than the risk for the classic papillary type. Overall, a 10-year survival of 76.6% in our patients was seen. Conclusions Patients with aggressive variants of PTC are more at risk for the development of metastatic disease. In these patients, established treatment modalities (surgery, radioiodine therapy) should be offered promptly, as well as close follow-up.

There are no comments yet on this publication. Be the first to share your thoughts.