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CD103 spurs on suppressors

Journal of Experimental Medicine
The Rockefeller University Press
Publication Date
DOI: 10.1084/jem2028iti2
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  • Biology
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2028iti IN THIS ISSUE JEM Vol. 202, No. 8, 2005 1014 CD103 spurs on suppressors An integrin expressed by gut dendritic cells (DCs) gives regulatory T (T reg) cells the green light for suppression, according to a study on page 1051. Annacker and colleagues show that DCs expressing the integrin CD103 are re- quired for T reg cells to subdue gut- attacking effector T cells in a mouse model of inflammatory bowel disease (IBD). Naturally occurring T reg cells help protect against autoimmunity and exces- IBD in mice (right) is suppressed by T reg cells only if dendritic cells express CD103. which is released from vagus nerve endings upon stimulation. Acetylcholine binds to nicotinic receptors on macrophages, thus inhibiting the synthesis and release of inflammatory cytokines such as TNF and interleukin (IL)-6. Luyer et al. now show that the antiinflammatory effect of fat consumption in the rat model of hemorrhagic shock requires both CCK and the vagus nerve, as blocking CCK or severing the vagus nerve abolished this effect. With the vagus nerve intact, fat- induced CCK inhibited the production of circulating TNF and IL-6 and reduced gut permeability. Blocking nicotinic receptors also eliminated the antiinflammatory effects of dietary fat, thus solidifying the connection between fat-induced CCK and the cholinergic antiinflammatory pathway. The authors think that this pathway might be important in suppressing gut inflammation in response to food proteins and normal gut bacteria, which immune cells might otherwise regard as foreign invaders. They also suggest that this pathway could potentially be targeted in patients as a way to reduce inflammatory complications after surgery. Fat fights inflammation Dietary fat triggers the cholinergic antiinflammatory pathway via the vagus nerve. A study on page 1023 reveals a potential benefit of much-maligned high fat foods. According to Luyer and colleagues, the same hormone that makes you f

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