Affordable Access

Publisher Website

Evaluation of the efficacy of two carbamates, physostigmine and pyridostigmine, when used in conjunction for protection against organophosphate exposure

Authors
Journal
Fundamental and Applied Toxicology
0272-0590
Publisher
Elsevier
Publication Date
Volume
15
Issue
4
Identifiers
DOI: 10.1016/0272-0590(90)90197-r
Disciplines
  • Medicine

Abstract

Abstract Recent studies have shown that pretreatment with either pyridostigmine (PYR) or physostigmine (PHY) followed by atropineoxime therapy is very effective in reducing the lethality of nerve agents. The therapeutic efficacy of a PHY and PYR combination pretreatment was evaluated in guinea pigs challenged with two LD50s of soman. Endpoints measured were percentage of acetylcholinesterase inhibition induced by the pretreatment and survival up to 24 hr postchallenge. Response surface methodology was employed to describe the relationship between each endpoint and the pretreatment combination. Although both carbamates contributed to blood acetylcholinesterase inhibition, PHY alone protected as well as the optimal dose of the combination.

There are no comments yet on this publication. Be the first to share your thoughts.