Abstract The Xinjie mafic–ultramafic layered intrusion in the Emeishan large igneous province (ELIP) hosts Cu–Ni–platinum group element (PGE) sulfide ore layers within the lower part and Fe–Ti–V oxide-bearing horizons within the middle part. The major magmatic Cu–Ni–PGE sulfide ores and spatially associated cumulate rocks are examined for their PGE contents and Re–Os isotopic systematics. The samples yielded a Re–Os isochron with an age of 262 ± 27 Ma and an initial 187Os/ 188Os of 0.12460 ± 0.00011 ( γ Os( t) = −0.5 ± 0.1). The age is in good agreement with the previously reported U–Pb zircon age, indicating that the Re–Os system remained closed for most samples since the intrusion emplacement. They have near-chondritic γ Os( t) values ranging from −0.7 to −0.2, similar to those of the Lijiang picrites and Song Da komatiites. Exceptionally, two samples from the roof zone and one from upper sequence exhibit radiogenic γ Os( t) values (+0.6 to +8.6), showing minor contamination by the overlying Emeishan basalts. The PGE-rich ores contain relatively high PGE and small amounts of sulfides (generally less than 2%) and the abundance of Cu and PGE correlate well with S, implying that the distribution of these elements is controlled by the segregation and accumulation of a sulfide liquid. Some ore samples are poor in S (mostly <800 ppm), which may due to late-stage S loss caused by the dissolution of FeS from pre-existing sulfides through their interaction with sulfide-unsaturated flowing magma. The combined study shows that the Xinjie intrusion may be derived from ferropicritic magmas. The sharp reversals in Mg#, Cr/FeO T and Cr/TiO 2 ratios immediately below Units 2–4, together with high Cu/Zr ratios decreasing from each PGE ore layer within these cyclic units, are consistent with multiple magma replenishment episodes. The sulfides in the cumulate rocks show little evidence of PGE depletion with height and thus appear to have segregated from successive inputs of fertile magma. This suggests that the Xinjie intrusion crystallized from in an open magma system, e.g., a magma conduit. The compositions of the disseminated sulfides in most samples can be modeled by applying an R factor (silicate–sulfide mass ratio) of between 1000 and 8000, indicating the segregation of only small amounts of sulfide liquid in the parental ferropicritic magmas. Thus, continuous mixing between primitive ferropicritic magma and differentiated resident magma could lead to crystallization of chromite, Cr-bearing magnetite and subsequently abundant Fe–Ti oxides, thereby the segregation of PGE-rich Cu-sulfide. When considered in the light of previous studies on plume-derived komatiites and picrites worldwide, the close-to-chondritic Os isotopic composition for most Xinjie samples, Lijiang picrites and Song Da komatiites suggest that the ferropicritic magma in the ELIP were generated from a plume. This comprised recycled Neoproterozic oceanic lithosphere, including depleted peridotite mantle embedded with geochemically enriched domains. The ascending magmas thereafter interacted with minor (possibly <10%) subducted/altered oceanic crust. This comparison suggests that the komatiitic melts in the ELIP originated from a greater-than normal degree of melting of incompatible trace element depleted, refractory mantle components in the plume source.