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Synthesis and properties of a biocompatible analogue for β-turn protein structural motifs based on 5-amino-3-pentynoic acid

Authors
Journal
Tetrahedron Letters
0040-4039
Publisher
Elsevier
Publication Date
Volume
37
Issue
38
Identifiers
DOI: 10.1016/0040-4039(96)01514-6

Abstract

Abstract 5-Amino-3-pentynoic acid, a new ‘lightly’ constrained amino acid surrogate for glycylglycine and model for dipeptide homologues was prepared from propagylamine and methods were devised for its incorporation into linear oligopeptides through both C- and N-terminal extension.

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