Affordable Access

Publisher Website

The metabolism of benzo(a)pyrene by the lungs of asbestos exposed rats

Authors
Journal
Experimental Pathology
0232-1513
Publisher
Elsevier
Publication Date
Volume
26
Issue
2
Identifiers
DOI: 10.1016/s0232-1513(84)80076-6
Keywords
  • Benzo(A)Pyrene
  • Lung
  • Asbestos
  • Pathogenicity
  • Crocidolite

Abstract

Summary A group of Fischer F344 rats were exposed to an aerosol of crocidolite asbestos for 36 d. Short-term organ cultures were established from the lungs of these animals and from a similar control group. The ability of these cultures to metabolise benzo(a)pyrene to water-soluble and ether-soluble forms was measured. Crocidolite treatment reduced the lungs ability to produce both types of metabolite although only the reduction in water-soluble forms was significant. DNA binding increased in cultures from treated rats, though this was not statistically significant. The possible relationship of these results to asbestos pathogenesis is discussed.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

The expressions of protooncogenes and CYP1A in lun...

on Regulatory toxicology and phar... June 2006

The expressions of protooncogenes and CYP1A in lun...

on Regulatory Toxicology and Phar... Jan 01, 2006

The metabolism of benzo(a)pyrene in isolated perfu...

on Acta pharmacologica et toxicol... August 1977
More articles like this..