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CMR assessment of myocardial mechanics and tissue characterization in patients treated with Anthracycline chemotherapy for acute myeloid leukaemia

Authors
Journal
Journal of Cardiovascular Magnetic Resonance
1097-6647
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Volume
14
Identifiers
DOI: 10.1186/1532-429x-14-s1-p182
Keywords
  • Poster Presentation
Disciplines
  • Medicine
  • Physics

Abstract

CMR assessment of myocardial mechanics and tissue characterization in patients treated with Anthracycline chemotherapy for acute myeloid leukaemia POSTER PRESENTATION Open Access CMR assessment of myocardial mechanics and tissue characterization in patients treated with Anthracycline chemotherapy for acute myeloid leukaemia Christopher A Miller1,2*, Rahul Potluri1,2, Matthias Schmitt1,2 From 15th Annual SCMR Scientific Sessions Orlando, FL, USA. 2-5 February 2012 Background Anthracycline-associated cardiomyopathy is a progres- sive, dose-dependent complication of Anthracycline che- motherapy. The period between Anthracycline therapy and onset of overt heart failure is often years, even dec- ades, and as such Anthracyclines appear to initiate a myocardial injury that remains clinically silent for a sub- stantial period of time. Left ventricular (LV) ejection fraction (EF) is often preserved during this latent period. A more sensitive marker of Anthracycline-associated myocardial injury would allow earlier diagnosis, hence potentially earlier initiation of cardioprotective therapy, and better prognostication. We assessed the relationship between cumulative Anthracycline dose and myocardial function (global and regional) and myocardial fibrosis (focal and diffuse) in patients who had previously received Anthracycline che- motherapy for acute myeloid leukaemia (AML) with normal or near normal LV EF. Methods 15 patients with a prior history of AML underwent 1.5T CMR (Avanto, Siemens). LV volumetric analysis was performed on SSFP images. Mitral inflow was assessed using phase-contrast velocity mapping. Spatial modula- tion of magnetization was performed on a mid-ventricu- lar short-axis slice in order to assess peak systolic circumferential strain (εcc). T1 mapping was performed pre- and 10-minutes post 0.15mmol/kg gadolinium- DTPA using a modified look locker inversion recovery sequence. ΔR1 ratio [(1/T1myocardium post-contrast) - (1/T1myocardium pre-contrast)] / [(1/T1blood pos

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