Affordable Access

Publisher Website

Study of the electrooxidative behaviour of 5-hydroxyindole-3-acetic acid, 5-hydroxytryptophan and serotonine in the presence of sodium ethylenediaminetetraacetic acid

Journal of Electroanalytical Chemistry
Publication Date
DOI: 10.1016/0022-0728(84)80047-9


Abstract The great instability of the indole derivatives 5-hydroxytryptophan (5-HTP), serotonine (5-HT) and 5-hydroxyindole-3-acetic acid (5-HIAA) in strong acid medium and the protective role of sodium ethylenediaminetetracetate (EDTA H 2Na 2) could be explained by their electrooxidative behaviour on a carbon paste electrode. Voltamperometric curves obtained in a 1–8 pH range show that oxidation occurs in two irreversible steps; the mechanism is more complex than a simple electron transfer. For the three molecules, new redox couples have been detected on cyclic voltammograms at lower potentials than the parent compound, indicating that more easily oxidized derivatives are formed. On the other hand, the anodic oxidation of EDTA H 2Na 2 has been investigated and in the present case the molecule is not acting by complexing metal traces but should actually be considered a competitive agent preventing the second oxidation step of the indole derivatives.

There are no comments yet on this publication. Be the first to share your thoughts.


Seen <100 times

More articles like this

[5-Hydroxyindole acetic acid (5HIAA)].

on Nihon rinsho. Japanese journal... March 1995

[5-hydroxyindole acetic acid (5HIAA)].

on Nihon rinsho. Japanese journal... December 1999

[5-Hydroxyindole acetic acid (5HIAA)].

on Nihon rinsho. Japanese journal... August 2005

The dietary supplement 5-hydroxytryptophan and uri...

on CMAJ : Canadian Medical Associ... Apr 08, 2008
More articles like this..