Affordable Access

Publisher Website

Simple camphor derivatives as chiral auxiliaries for asymmetric conjugate addition

Authors
Journal
Tetrahedron
0040-4020
Publisher
Elsevier
Publication Date
Volume
41
Issue
24
Identifiers
DOI: 10.1016/s0040-4020(01)91437-1

Abstract

Abstract The chiral enoates, 4 , readily available in two simple steps from (+)-camphor, Undergo asymmetric conjugate addition with the Gilman reagent LiBu 2Cu. Chemical yields are high (70–90%) and in the case of the naphthyl-substituted enoate 4e excellent diastereoselectivity (95% d.e. ) is observed. 3-Methyl-heptan-l-ol of correspondingly high enantiomeric purity is obtained by reduction of the conjugate adduct with lithium aluminium hydride.

There are no comments yet on this publication. Be the first to share your thoughts.