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Tissue distribution and aortic binding ofdl-glyceraldehyde-C14

Authors
Journal
Journal of Surgical Research
0022-4804
Publisher
Elsevier
Publication Date
Volume
5
Issue
3
Identifiers
DOI: 10.1016/s0022-4804(65)80005-1

Abstract

Summary A study has been conducted of the in vivo tissue distribution of intravenously administered dl-glyceraldehyde-C 14in male Wistar rats and of the in vitro glyceraldehyde-binding properties of segments of native bovine aortas and of aortic elastin. The data indicate that the aortic wall can selectively bind glyceraldehyde, which is a potent cross-linking (i.e., tanning) agent of both metabolic and dietary origin. The possibility is raised that such binding may provide a means toward a unified explanation for the pathogenesis of certain of the properties of the arteriosclerotic aortic wall.

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