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The antipyretic effect of NG-nitro-l-arginine methyl ester is related to its influence on metabolism

Authors
Journal
Journal of Thermal Biology
0306-4565
Publisher
Elsevier
Publication Date
Volume
25
Identifiers
DOI: 10.1016/s0306-4565(99)00071-6
Keywords
  • Body Temperature
  • L-Name
  • Lps Fever
  • Metabolic Rate
  • Rabbits

Abstract

Abstract Thermoregulatory responses (rectal and ear skin temperatures, metabolic rate, respiratory rate), after treatment with N G-nitro- l-arginine methyl ester ( l-NAME), were investigated in normothermic and febrile rabbits at an ambient temperature of 20±1°C. In endotoxin challenged rabbits, l-NAME (25 mg/kg i.v.) given 30 min before LPS (1 μg/kg i.v.) significantly reduced fever response, while did not influence body temperature in saline treated animals. The antipyretic action of l-NAME was caused mainly due to inhibition of metabolic rate.

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