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Modeling of nanofiltration - assisted organic synthesis

Authors
Journal
Journal of Membrane Science
0376-7388
Publisher
Elsevier
Publication Date
Volume
163
Issue
2
Identifiers
DOI: 10.1016/s0376-7388(99)00175-1
Keywords
  • Nanofiltration Membranes
  • Organic Synthesis
  • Reaction/Separation Model
  • Parametric Study
Disciplines
  • Pharmacology

Abstract

Abstract The molecular weight of target compounds in many organic syntheses in the pharmaceutical industry is in the range of 300–1000 Da. Separation processes based on organic solvent-resistant nanofiltration membranes are being explored to separate these valuable products from the smaller molecular weight products and residual reactants present in the reaction mixture. Through numerical modeling and use of realistic values for the parameters in organic syntheses involving compounds of diverse molecular weights and hence, diverse sizes, this study shows that the production of the target compound can be enhanced significantly using nanofiltration. Enhancement is examined from the perspectives of conversion (yield), reduction of reaction time, selectivity and potential elimination of subsequent downstream separation steps.

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