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Polycyclitols: synthesis of novel carbasugar and conduritol analogues as potential glycosidase inhibitors

Authors
Publisher
Elsevier Science
Publication Date
Keywords
  • Organic Chemistry
Disciplines
  • Chemistry

Abstract

Stereoselective syntheses of a new family of hydrindane based bicyclitols with seven hydroxyl groups in a diverse stereochemical array have been accomplished from readily available building-blocks. One of the bicyclitols 12 has been found to exhibit moderate a-glucosidase inhibitory activity in enzymatic assays.

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