Abstract A self contained, Master Slave Manipulator operated and largely disposable apparatus for the large scale production of [ 18F]FDG using nucleophilic fluorination methodology has been developed. The synthetic unit consists of readily available sterile disposable components and is easy to assemble. Operation of the synthetic unit is carried out in a hot cell under a closed system to minimize radiation exposure to personnel. Recovery of [ 18O]water by direct distillation from the reaction vial makes the system even more attractive. Normal production runs yield 25–150 mCi of [ 18F]FDG. Since no manual handling of radioactivity is involved, a scaled up production is feasible by this procedure. Synthesis is based on the nucleophilic fluorination of 22.214.171.124-tetra-O-acetyl-2-O-trifluoromethanesulfonyl-β- d-mannopyranose (tetraacetyl precursor). We have avoided the use of any permanent electrical liquid transfer devices in our system, thereby eliminating the possibility of pyrogen build up. An in-house radiopharmaceutical program to check the sterility and apyrogenicity of the short-lived radiopharmaceuticals is an added convenience at our institution.