Affordable Access

Publisher Website

Formalin-induced nociceptive responses in diabetic mice

Authors
Journal
Neuroscience Letters
0304-3940
Publisher
Elsevier
Publication Date
Volume
149
Issue
2
Identifiers
DOI: 10.1016/0304-3940(93)90761-9
Keywords
  • Diabetes
  • Nociception
  • Formalin
  • Substance P
  • Naltrindole
  • Spantide

Abstract

Abstract In non-diabetic mice, s.c. injection of formalin to the hindpaw had a biphasic effect: an immediate nociceptive response (first-phase) followed by a tonic response (second-phase). However, only the immediate nociceptive response was observed in diabetic mice. The duration of the first-phase response was significantly longer in diabetic mice than in non-diabetic mice. In diabetic mice, when spantide, an antagonist of substance P, reduced the duration of the nociceptive response in the first-phase to the levels that were observed in non-diabetic mice, the second-phase response appeared. The second phase also became apparent in diabetic mice after pretreatment with naltrindole (3 mg/kg), an antagonist of δ-opioid receptors. These results suggest that a negative control system, which is mediated by δ-opioid receptors and links substance P with somatostatin-mediated nociceptive transmission, may inhibit the formalin-induced second-phase of the nociceptive response in diabetic mice.

There are no comments yet on this publication. Be the first to share your thoughts.

Statistics

Seen <100 times
0 Comments

More articles like this

Formalin-induced nociceptive responses in diabetic...

on Neuroscience Letters Jan 12, 1993

Effects of mexiletine on formalin-induced nocicept...

on Research communications in che... May 1993

Meta-chlorophenylpiperazine attenuates formalin-in...

on British Journal of Pharmacolog... December 1995

The role of spinal δ1-opioid receptors in inhibiti...

on European Journal of Pharmacolo... Jan 01, 1997
More articles like this..