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Structure-activity relationships of the non-peptidyl growth hormone secretagogue L-692,429

Authors
Journal
Bioorganic & Medicinal Chemistry Letters
0960-894X
Publisher
Elsevier
Publication Date
Volume
4
Issue
22
Identifiers
DOI: 10.1016/s0960-894x(01)80702-2

Abstract

Abstract Systematic investigation of the amino acid sidechain of L-692,429, the prototype of a novel class of benzolactam growth hormone (GH) secretagogues, has led to the preparation of L-692,585, a 2(R)-hydroxypropyl amino analog, which is twenty times more potent in vitro than L-692,429. Additional amino modifications reported here further define the structure-activity profile for L-692,429.

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