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Glucose oxidation and monoamine oxidase activity from the fibroblasts of schizophrenic patients and controls

Authors
Journal
Life Sciences
0024-3205
Publisher
Elsevier
Publication Date
Volume
56
Issue
19
Identifiers
DOI: 10.1016/0024-3205(95)00131-o
Keywords
  • Schizophrenia
  • Fibroblast
  • Monoaminc Oxidase
  • Glucose Oxidation
Disciplines
  • Chemistry
  • Ecology
  • Geography
  • Medicine

Abstract

Abstract Fibroblasts have emerged as one of the best systems in which to study several genetically inherited diseases. Their use avoids the contaminating effects of medication and other environmental factors. Moreover, fibroblast cells cultured in vitro can express several biochemical parameters which are characteristic of neuronal cells. We have studied fibroblast MAO-A and glucose oxidation and platelet MAO-B from schizophrenic patients and control subjects. Fibroblasts from schizophrenics showed an increased glucose oxidation in two different experiments conducted (122% and 126% compared to controls). No changes were found in the levels of fibroblast MAO-A or platelet MAO-B activity. Possibly these alterations in glucose oxidation may be associated with a generalized membrane abnormality which has been reported in schizophrenia

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