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Oxidative Stress, Molecular Inflammation and Sarcopenia

Authors
Journal
International Journal of Molecular Sciences
1422-0067
Publisher
MDPI AG
Publication Date
Volume
11
Issue
4
Identifiers
DOI: 10.3390/ijms11041509
Keywords
  • Review
Disciplines
  • Biology
  • Medicine

Abstract

Sarcopenia is the decline of muscle mass and strength with age. Evidence suggests that oxidative stress and molecular inflammation play important roles in age-related muscle atrophy. The two factors may interfere with the balance between protein synthesis and breakdown, cause mitochondrial dysfunction, and induce apoptosis. The purpose of this review is to discuss some of the major signaling pathways that are activated or inactivated during the oxidative stress and molecular inflammation seen in aged skeletal muscle. Combined interventions that may be required to reverse sarcopenia, such as exercise, caloric restriction, and nutrition, will also be discussed.

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