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HIV-1 generevresponsible for accumulated heterodisperse RNAs seen in infected T-Cells

Authors
Journal
Virology
0042-6822
Publisher
Elsevier
Publication Date
Volume
186
Issue
1
Identifiers
DOI: 10.1016/0042-6822(92)90092-4
Disciplines
  • Biology

Abstract

Abstract To analyze which gene of HIV-1 was responsible for the high accumulation of “heterodisperse RNAs” in virally infected T-cells, Northern blot analysis was performed. Total RNA from inducible cell lines expressing the envelope protein of HIV-1, or the regulatory gene rev, were blotted and hybridized with an Alu probe that detects heterodisperse RNAs. Results show that the rev gene is responsible for the accumulation of cellular heterodisperse RNAs seen earlier in HIV-1-infected T-cells.

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