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The photochemistry of indomethacin

Authors
Journal
Journal of Photochemistry and Photobiology A Chemistry
1010-6030
Publisher
Elsevier
Publication Date
Volume
61
Issue
1
Identifiers
DOI: 10.1016/1010-6030(91)85071-n
Disciplines
  • Chemistry

Abstract

Abstract The photochemistry of the anti-inflammatory drug Indomethacin ( N-( para-chlorobenzoyl)-5-methoxy-2-methylindole-3-acetic acid ( 1) was investigated. Unlike previously examined N-carbonyl-substituted indoles, which undergo photo-Fries rearrangement and photocycloaddition to alkenes, Indomethacin yields products derived from photochemical decarboxylation of the acetic acid side chain. Indomethacin also exhibits unusual long wavelength fluorescence which is ascribed to a charge transfer singlet excited state.

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