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Lipoatrophy Revisited

Authors
Publisher
Elsevier Ltd
Publication Date
Volume
11
Issue
10
Identifiers
DOI: 10.1016/s1043-2760(00)00309-x
Keywords
  • Adipose Tissue
  • Diabetes
  • Lipoatrophy
  • Leptin
  • Insulin Resistance
  • Tissue Triglyceride
  • Animal Models
  • Lamin
Disciplines
  • Medicine

Abstract

Abstract The lipoatrophy syndromes are a heterogeneous group of syndromes characterized by a paucity of adipose tissue. Severe lipoatrophy is associated with insulin-resistant diabetes mellitus (DM). The loss of adipose tissue can have a genetic, immune, or infectious/drug-associated etiology. Causative mutations have been identified in patients for one form of partial lipoatrophy – Dunnigan-type familial partial lipodystrophy. Experiments using lipoatrophic mice demonstrate that the diabetes results from the lack of fat and that leptin deficiency is a contributing factor. Thiazolidinedione therapy improves metabolic control in lipoatrophic patients; the efficacy of leptin treatment is currently being investigated.

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