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Structure-activity relationships among mycotoxins

Authors
Journal
Chemico-Biological Interactions
0009-2797
Publisher
Elsevier
Publication Date
Volume
71
Identifiers
DOI: 10.1016/0009-2797(89)90030-6
Keywords
  • Mycotoxins
  • Structure-Activity
  • Toxicity
  • Mutagenicity
  • Genotoxicity
  • Carcinogenicity
  • Mode Of Action
Disciplines
  • Biology
  • Chemistry
  • Medicine

Abstract

Abstract Relationships between structural features and biological effects of mycotoxins are reviewed. Structure-activity relationships are characterized at the molecular, subcellular, cellular, or supracellular level. Major chemical and physicochemical factors responsible for bioactivity of mycotoxins are stressed. A variety of chemical families of mycotoxins are then discussed from the point of view of structure-activity relationships. The structurally related families comprise small lactones, macrocyclic lactones, isocoumarin derivatives, aflatoxins and related compounds trichothecenes, anthraquinones, indole-derived tremorgens and selected amino acid-derived mycotoxins such as sporidesmins and cyclosporines. Biological effects of mycotoxins include acute and chronic toxicity, antimicrobial activity, mutagenicity and genotoxicity, carcinogenicity and biochemical modes of action.

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