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Combination therapy in the management of LUTS – is this the future?

Authors
Journal
Drug Discovery Today Therapeutic Strategies
1740-6773
Publisher
Elsevier
Volume
9
Issue
1
Identifiers
DOI: 10.1016/j.ddstr.2012.03.001
Disciplines
  • Medicine

Abstract

The treatment of LUTS (Lower Urinary Tract Symptoms) has evolved from primarily surgical to medical management. Medical management itself has evolved from single agent to combination therapy. Treatments for BPH (Benign Prostatic Hyperplasia) are aimed at improving subjective symptoms and quality of life. α-Blockers and 5-α reductase inhibitors are the two main categories for treatment. In addition, both antimuscarinic agents and phosphodiesterase inhibitors have been shown to be effective in the management of LUTS. We discuss the current role of these agents in combination for the management of LUTS associated with BPH.

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