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Expression of disodium cromoglygate ‘protective’ effects observed during V79 cell proliferation

Authors
Journal
Chemico-Biological Interactions
0009-2797
Publisher
Elsevier
Publication Date
Volume
89
Identifiers
DOI: 10.1016/0009-2797(93)90002-g
Keywords
  • Cytotoxicity Protection
  • Disodium Cromoglycate
  • Cell Proliferation
  • Colony Formation
  • Unbalanced Growth
  • Cell Metabolism
  • Membrane Stability
Disciplines
  • Biology

Abstract

Abstract Disodium cromoglycate (DSCG) in equimolar concentration of 0.56 μmol/l preincubated with an asynchronous cell population decreases the inhibition of proliferation and results in a 100% elimination of inhibition of colony formation induced by benfluron (BF). DSCG protects the cells from unbalanced growth and unbalanced metabolism (e.g., prevention of increase or decrease in protein cell content, glycolytic activity and in amino acid metabolism) which are both the integrating parts of BF cytotoxic reaction. The protective effect of DSCG is manifested also on synchronous cell populations, particularly in G 2 phase (26%). DSCG also stabilizes cell membrane by preventing the alterations of its permeability caused by the cytolytic concentrations of benfluron (at a concentration of 1.05 μmol/l and more).

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